5-Meo-Dmt | 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)

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What Is 5-MeO-DMT?

5-Meo-DMT or 5-methoxy-N, N-dimethyltryptamine is a ring-substituted indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to a terminal amino group via an ethyl side chain. 5-Meo-DMT is substitute_d at R5 of its indole heterocycle with a methoxy (MeO) functional group CH3O−; it also contains two methyl groups CH3- bound to the terminal amine RN of its tryptamine backbone (DMT). 5-Meo-DMT is the N-substituted methyl homolog of 5-MeO-MiPT, although it radically differs in its effects.

It is foun_d in a wide variety of plant species, as well as in the venom of a single psychoactive toad species (Bufo Alvaris). Like its close relatives DMT and bufotenin (5-HO DMT), it has been used as an entheogen by South American shamans for thousands of years. In modern times, however, it is primarily acquire_d in its synthetic powder form through the use of online research chemical vendors.

EFFECTS

• Tactile enhancement – This particular component is perhaps the most overwhelming sensation within the entirety of the 5-MeO-DMT experience. It increases the intensity of tactile sensations to such an overwhelming extent that it can induce a sensation of sustained and repeatable full body orgasm within every nerve ending across the entire body to a degree not found within any other psychedelic drug. The experience of this results in the perception of having difficulty sustaining the act of breathing. It is worth noting, however, that this is not a genuine or dangerous experience of respiratory depression and is considered to be safe.
• Bodily control enhancement
• Bodily pressures
• Changes in gravity
• Euphoria
• Motor control loss
• Nausea
• Perception of increased weight
• Pupil dilation
• Skin flushing
• Temperature regulation suppression
• Cognitive effects
• Amnesia
• Analysis enhancement
• Anxiety
• Conceptual thinking
• Delusions
• Subconscious communication
• Emotion enhancement
• Increased music appreciation
• Memory suppression
• Ego death
• Mindfulness
• Thought connectivity
• Time distortion
• Unity and interconnectedness
• Wakefulness

WHAT TO EXPECT

Effects come on strong, often with a loss of physical coordination and control. Users experience bright colors, moving environments, or recursive patterns, and perhaps even “environmental orbism” at higher doses. However, visual effects are limited. Unlike DMT, 5-MeO DMT isn’t known for its visionary properties. The experience is more often described as a “perspective shift” characterized by physical, emotional, and conceptual effects.

One of the most common features of the 5-methoxy-N experience is an enhancement of tactile awareness to the point of sensory overload. The body may also feel heavier. Intense emotions are typical, ranging from extreme fear to euphoria, and especially include anxiety or excitement during onset. It’s common to experience an overwhelming sense of oneness with the universe, or a sense of being outside of time and space while seeming to experience the totality of both. The concept of the ego as a separate entity is typically lost. Other effects include auditory hallucinations, time distortion, nausea, and memory loss.

PRECAUTIONS

5-Meo-DMT should not be taken with some antidepressants. Combining them may cause severe hypertensive symptoms (elevated blood pressure, heart rate, and temperature), seizures, long-term kidney damage, serotonin syndrome, and death. Those new to 5-MeO-DMT should start out with a low dose, weighed on a scale accurate to 0.002 g (2 mg). Since people tend to react differently to the same doses (and it’s not entirely clear why) caution is advisable even if you have prior experience with tryptamines.

FINDING YOUR RIGHT DOSAGE

Taken in the presence of a sitter with no other drugs or contraindicated medications (like MAOI antidepressants), it appears to be relatively safe. Otherwise, persistent anxiety has been reported after just one use, along with sleep disruption and panic attacks. To help minimize the risks, it’s a good idea to start with low, precisely measured doses, and have an experienced sitter present.

One of the interesting things about it is that the duration of the effect is anywhere from 20 to 60 minutes.

MEDICAL USE

the Crossroads Treatment Center in Northern Mexico, which specializes in combination ibogaine and 5-MeO-DMT therapy. It seems to work synergistically with the ibogaine, by allowing patients to integrate the ibogaine with a transcendental or mystical experience. It helps patients recontextualize their experience and ultimately can give them inspiration and motivation.

DMT also appears in many plants and animals, including the venom of a particular toad. DMT is more like a perspective shift. Some have said it’s something like a near-death experience.